A Comparative Study to Evaluate Efficacy of Curcumin and Aloe Vera Gel along with Oral Physiotherapy in the Management of Oral Submucous Fibrosis: A Randomized Clinical Trial

Rationale (Hypothesis): The antioxidant,anti-inflammatory,immunomodulatory and anti-tumorigenic properties of natural plant’s extracts like aloe Vera curcumin may produce beneficial therapeutic effects on OSMF patients lead to their symptomatic relief. Also, increase in the tissue elasticity with help oral physiotherapy excercises , would reinforcing increment mouth opening. Aim: aim study is compare efficacy Curcumin gel Aloe when both are supplemented along management OSMF. Materials methods: A parallel group trial design, using simple randomization technique, was conducted confirmed cases Patients were divided into two groups, one group(30 patients) given gel(Curenext) other (30 (Aloe 100% relief) each asked do same supplementally. Follow-up done for 6 weeks assessed basis improvement opening burning sensation at 2, 4, weeks. Results: There an parameters subsequent visits, but showed better than after treatment which highly statistically significant p < 0.01. Conclusion: effective improving symptoms, more efficacious without any side effects. Hence, we can advocate these drugs as adjuvant addition recommended treatment.